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1

Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer’s disease

Hani Atamna, William H. Frey II

Journal:

Year:

2007

Language:

english

File:

PDF, 270 KB

english, 2007

2

The clinical correlates of high-titer IgG anti-GMl antibodies

Thomas A. Ala, William H. Frey II

Journal:

Annals of Neurology

Year:

1994

Language:

english

File:

PDF, 121 KB

english, 1994

3

Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system

Shyeilla V. Dhuria, Leah R. Hanson, William H. Frey II

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 210 KB

english, 2009

4

Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

Shyeilla V. Dhuria, Leah R. Hanson, William H. Frey II

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 325 KB

english, 2010

5

Polyethylene glycol interferes with protein molecular weight determinations by gel filtration

Sau-chi B. Yan, Deborah Anne Tuason, V.B. Tuason, William H. Frey II

Journal:

Analytical Biochemistry

Year:

1984

Language:

english

File:

PDF, 309 KB

english, 1984

6

Inconsistency between severe substantia nigra degeneration with Lewy bodies and clinical parkinsonism in dementia patients: a cliniconeuropathological study

T. A. Ala, K.-H. Yang, J. H. Sung, W. H. Frey II

Journal:

Acta Neuropathologica

Year:

2000

Language:

english

File:

PDF, 379 KB

english, 2000

7

Clinical parkinsonism in dementia patients with substantia nigra Lewy bodies

T. A. Ala, K.-H. Yang, J. H. Sung, W. H. Frey II

Journal:

Journal of Neural Transmission

Year:

1999

Language:

english

File:

PDF, 401 KB

english, 1999

8

Catecholamine-Sensitive Guanylate Cyclase from Human Caudate Nucleus

William H. Frey II, Susan E. Senogles, Leonard L. Heston, Vicente B. Tuason, Susan E. Nicol

Journal:

Journal of Neurochemistry

Year:

1980

Language:

english

File:

PDF, 1.16 MB

english, 1980

9

Effect of Dopamine on Activation of Rat Striatal Adenylate Cyclase by Free Mg2+ and Guanyl Nucleotides

John D. McSwigan, Susan E. Nicol, I. I. Gottesman, V. B. Tuason, William H. Frey II

Journal:

Journal of Neurochemistry

Year:

1980

Language:

english

File:

PDF, 756 KB

english, 1980

10

Postmortem Stability of Dopamine-Sensitive Adenylate Cyclase, Guanylate Cyclase, ATPase, and GTPase in Rat Striatum

Susan E. Nicol, Susan E. Senogles, Thomas P. Caruso, James J. Hudziak, John D. McSwigan, William H. Frey II

Journal:

Journal of Neurochemistry

Year:

1981

Language:

english

File:

PDF, 470 KB

english, 1981

11

d-Aspartate in Human Brain

Eugene H. Man, George H. Fisher, Iris L. Payan, Rodolfo Cadilla-Perezrios, Nancy M. Garcia, Radhika Chemburkar, Georgine Arends, William H. Frey II

Journal:

Journal of Neurochemistry

Year:

1987

Language:

english

File:

PDF, 618 KB

english, 1987

12

Chlamydophila (Chlamydia) pneumoniae in the Alzheimer's brain

Hervé C. Gérard, Ute Dreses-Werringloer, Kristin S. Wildt, Srilekha Deka, Cynthia Oszust, Brian J. Balin, William H. Frey II, Elizabeth Z. Bordayo, Judith A. Whittum-Hudson, Alan P. Hudson

Journal:

FEMS Immunology & Medical Microbiology

Year:

2006

Language:

english

File:

PDF, 1.48 MB

english, 2006

13

Stimulation of guanylate cyclase by EDTA and other chelating agents

William H. Frey II, Susan E. Senogles, Vicente B. Tuason, Susan E. Nicol

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1981

Language:

english

File:

PDF, 420 KB

english, 1981

14

Quantitative analysis of the olfactory pathway for drug delivery to the brain

Robert G. Thorne, Carolyn R. Emory, Thomas A. Ala, William H. Frey II

Journal:

Year:

1995

Language:

english

File:

PDF, 1.05 MB

english, 1995

15

Endogenous Alzheimer's brain factor and oxidized glutathione inhibit antagonist binding to the muscarinic receptor

William H. Frey II, Melissa M. Najarian, Kavita S. Kumar, Carolyn R. Emory, Patrick M. Menning, John C. Frank, Melissa N. Johnson, Thomas A. Ala

Journal:

Year:

1996

Language:

english

File:

PDF, 647 KB

english, 1996

16

Intranasal insulin as a therapeutic option in the treatment of cognitive impairments

Christian Benedict, William H. Frey II, Helgi B. Schiöth, Bernd Schultes, Jan Born, Manfred Hallschmid

Journal:

Experimental Gerontology

Year:

2011

Language:

english

File:

PDF, 191 KB

english, 2011

17

Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis

T.M Ross, P.M Martinez, J.C Renner, R.G Thorne, L.R Hanson, W.H Frey II

Journal:

Journal of Neuroimmunology

Year:

2004

Language:

english

File:

PDF, 676 KB

english, 2004

18

Subacute intranasal administration of tissue plasminogen activator increases functional recovery and axonal remodeling after stroke in rats

Zhongwu Liu, Yi Li, Li Zhang, Hongqi Xin, Yisheng Cui, Leah R. Hanson, William H. Frey II, Michael Chopp

Journal:

Neurobiology of Disease

Year:

2012

Language:

english

File:

PDF, 785 KB

english, 2012

19

Inactivation of the human brain muscarinic acetylcholine receptor by oxidative damage catalyzed by a low molecular weight endogenous inhibitor from Alzheimer’s brain is prevented by pyrophosphate analogs, bioflavonoids and other antioxidants

John R Fawcett, Elizabeth Z Bordayo, Kathy Jackson, Howard Liu, Jennifer Peterson, Aleta Svitak, William H Frey II

Journal:

Year:

2002

Language:

english

File:

PDF, 670 KB

english, 2002

20

Heme from Alzheimer's brain inhibits muscarinic receptor binding via thiyl radical generation

Homer D Venters Jr., Leo E Bonilla, Tara Jensen, Hart P Garner, Elizabeth Z Bordayo, Melissa M Najarian, Thomas A Ala, Ronald P Mason, William H Frey II

Journal:

Year:

1997

Language:

english

File:

PDF, 304 KB

english, 1997

21

Previously reported nerve growth factor levels are underestimated due to an incomplete release from receptors and interaction with standard curve media

John R Fawcett, Xueqing Chen, Yueh-Erh Rahman, William H Frey II

Journal:

Year:

1999

Language:

english

File:

PDF, 83 KB

english, 1999

22

Inhibitor of antagonist binding to the muscarinic receptor is elevated in Alzheimer's brain

William H. Frey II, Carolyn R. Emory, Marlyse E. Wiebenga, Sanjaya Saxena, Dominic Cardelli, Thomas A. Ala, Gary D. Tollefson

Journal:

Year:

1994

Language:

english

File:

PDF, 782 KB

english, 1994

23

Ionic regulation of antagonist binding to the human muscarinic cholinergic receptor of caudate nucleus

Gary D. Tollefson, Susan E. Senogles, William H. Frey II

Journal:

Journal of Psychiatric Research

Year:

1983

Language:

english

File:

PDF, 670 KB

english, 1983

24

Human and rodent amyloid-β peptides differentially bind heme: Relevance to the human susceptibility to Alzheimer’s disease

Hani Atamna, William H. Frey II, Novie Ko

Journal:

Archives of Biochemistry and Biophysics

Year:

2009

Language:

english

File:

PDF, 778 KB

english, 2009

25

Intranasally delivered TGF-β1 enters brain and regulates gene expressions of its receptors in rats

Yu-Ping Ma, Min-Min Ma, Song Ge, Rui-Bing Guo, Hua-Jun Zhang, William H. Frey II, Ge-Lin Xu, Xin-Feng Liu

Journal:

Brain Research Bulletin

Year:

2007

Language:

english

File:

PDF, 238 KB

english, 2007

26

The window of opportunity for treatment of focal cerebral ischemic damage with noninvasive intranasal insulin-like growth factor-I in rats

Xin-Feng Liu, John R Fawcett, Leah R Hanson, William H Frey II

Journal:

Journal of Stroke and Cerebrovascular Diseases

Year:

2004

Language:

english

File:

PDF, 285 KB

english, 2004

27

Intranasal administration delivers peptoids to the rat central nervous system

Tinna M. Ross, Ronald N. Zuckermann, Christoph Reinhard, William H. Frey II

Journal:

Neuroscience Letters

Year:

2008

Language:

english

File:

PDF, 558 KB

english, 2008

28

Intranasal delivery of siRNA to the olfactory bulbs of mice via the olfactory nerve pathway

Dan B. Renner, William H. Frey II, Leah R. Hanson

Journal:

Neuroscience Letters

Year:

2012

Language:

english

File:

PDF, 707 KB

english, 2012

29

Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype

M.A. Reger, G.S. Watson, W.H. Frey II, L.D. Baker, B. Cholerton, M.L. Keeling, D.A. Belongia, M.A. Fishel, S.R. Plymate, G.D. Schellenberg, M.M. Cherrier, S. Craft

Journal:

Neurobiology of Aging

Year:

2006

Language:

english

File:

PDF, 162 KB

english, 2006

30

Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

R.G. Thorne, G.J. Pronk, V. Padmanabhan, W.H. Frey II

Journal:

Year:

2004

Language:

english

File:

PDF, 661 KB

english, 2004

31

Delivery of interferon-β to the monkey nervous system following intranasal administration

R.G. Thorne, L.R. Hanson, T.M. Ross, D. Tung, W.H. Frey II

Journal:

Year:

2008

Language:

english

File:

PDF, 1.67 MB

english, 2008

32

Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis

J.A. Martinez, G.J. Francis, W.Q. Liu, N. Pradzinsky, J. Fine, M. Wilson, L.R. Hanson, W.H. Frey II, D. Zochodne, T. Gordon, C. Toth

Journal:

Year:

2008

Language:

english

File:

PDF, 1.93 MB

english, 2008

33

Lysosomal enzyme can bypass the blood–brain barrier and reach the CNS following intranasal administration

Daniel A. Wolf, Leah R. Hanson, Elena L. Aronovich, Zhenhong Nan, Walter C. Low, William H. Frey II, R. Scott McIvor

Journal:

Molecular Genetics and Metabolism

Year:

2012

Language:

english

File:

PDF, 424 KB

english, 2012

34

111 Hallucinations and signs of Parkinsonism help distinguish patients with dementia and cortical Lewy bodies from patients with Alzheimer's Disease at time of presentation

T.A. Ala, K.H. Yang, J.H. Sung, W.H. Frey II

Journal:

Neurobiology of Aging

Year:

1996

Language:

english

File:

PDF, 156 KB

english, 1996

35

475 Neuropathologic analysis of 799 cases of clinically demented patients

K.H. Yang, K.K. Choi, T.A. Ala, W.H. Frey II, J.H. Sung

Journal:

Neurobiology of Aging

Year:

1996

Language:

english

File:

PDF, 138 KB

english, 1996

36

Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion

Xin-Feng Liu, John R. Fawcett, Robert G. Thorne, William H. Frey II

Journal:

Neuroscience Letters

Year:

2001

Language:

english

File:

PDF, 121 KB

english, 2001

37

S3-04-03: Bypassing the blood-brain barrier with intranasal delivery to treat Alzheimer’s disease and related disorders

William H. Frey II

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 51 KB

english, 2006

38

O2-05-01: Intranasally administered deferoxamine improves spatial memory in APP/PS1 mice

Leah R. Hanson, Jared M. Fine, Nathan J. Tuttle, Dianne L. Marti, Rachel B. Matthews, Thuhien M. Nguyen, Aleta L. Svitak, S. Scott Panter, William H. Frey II

Journal:

Alzheimer's & Dementia

Year:

2007

Language:

english

File:

PDF, 48 KB

english, 2007

39

Nep-like proteases are important Aß degrading enzymes

Robert A. Marr, Daniel Hafez, Jeffrey Huang, Alexis Huynh, Angela Bruno, Stephanie Valtierra, Edward Rockenstein, Luc DesGroseillers, Bao Lu, William Frey II, Leah Hanson, David Bennett, Eliezer Masli

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 152 KB

english, 2010

40

Silica-ELISA method improves detection and quantitation of minor glycolipid components in lipid mixtures and of other antigens

W.H. Frey II, J.W. Schmalz, P.A. Perfetti, T.L. Norris, C.R. Emory, T.A. Ala

Journal:

Journal of Immunological Methods

Year:

1993

Language:

english

File:

PDF, 672 KB

english, 1993

41

Two cases of acute anti-GM1 antibody elevations in response to exogenous GM1 without neurological symptoms

T.A. Ala, P.A. Perfetti, W.H. Frey II

Journal:

Journal of Neuroimmunology

Year:

1994

Language:

english

File:

PDF, 482 KB

english, 1994

42

An open-label, prospective trial of cryospray ablation for Barrett's esophagus high-grade dysplasia and early esophageal cancer in high-risk patients

John A. Dumot, John J. Vargo II, Gary W. Falk, Lorraine Frey, Rocio Lopez, Thomas W. Rice

Journal:

Gastrointestinal Endoscopy

Year:

2009

Language:

english

File:

PDF, 1.62 MB

english, 2009

43

Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage

Xin-Feng Liu, John R Fawcett, Robert G Thorne, Terese A DeFor, William H Frey II

Journal:

Journal of the Neurological Sciences

Year:

2001

Language:

english

File:

PDF, 87 KB

english, 2001

44

Intranasal delivery of insulin via the olfactory nerve pathway

Dan B. Renner, Aleta L. Svitak, Nathan J. Gallus, Marna E. Ericson, William H. Frey II, Leah R. Hanson

Journal:

Journal of Pharmacy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.13 MB

english, 2012

45

Delivery of Neurotrophic Factors to the Central Nervous System

Robert G. Thorne, Dr William H. Frey II

Journal:

Clinical Pharmacokinetics

Year:

2001

Language:

english

File:

PDF, 490 KB

english, 2001

46

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Jessica Freiherr, Manfred Hallschmid, William H. Frey II, Yvonne F. Brünner…

Journal:

Year:

2013

Language:

english

File:

PDF, 359 KB

english, 2013

47

Cloning of a gene whose expression is increased in scrapie and in senile plaques in human brain

Wietgrefe, S, Zupancic, M, Haase, A, Chesebro, B, Race, R, Frey, II W, Rustan, T, Friedman, R L

Journal:

Alzheimer Disease & Associated Disorders

Year:

1987

File:

PDF, 78 KB

1987

48

Delivery of Nerve Growth Factor to the Brain via the Olfactory Pathway.

Chen, Xue-Qing, Fawcett, John R., Rahman, Yueh-Erh, Ala, Thomas a., {Frey II}, William H.

Journal:

Journal of Alzheimer's Disease

Year:

1998

Language:

english

File:

PDF, 197 KB

english, 1998

49

Delivery of Nerve Growth Factor to the Brain via the Olfactory Pathway

Chen, Xue-Qing, Fawcett, John R., Rahman, Yueh-Erh, Ala, Thomas A., Frey II, William H.

Journal:

Journal of Alzheimer's Disease

Year:

1998

Language:

english

File:

PDF, 194 KB

english, 1998

50

Intranasal AAV Mediated Gene Delivery and Expression of Human Iduronidase in the CNS: A Non-invasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type I

Belur, Lalitha R., Temme, Alexa, Podetz-Pedersen, Kelly M, Riedl, Maureen, Vulchanova, Lucy, Robinson, Nicholas, Hanson, Leah R, Kozarsky, Karen F, Orchard, Paul J, Frey II, William H, Low, Walter C,

Journal:

Human Gene Therapy

Year:

2017

Language:

english

File:

PDF, 1.20 MB

english, 2017